Ribosomal dysregulation: A conserved pathophysiological mechanism in human depression and mouse chronic stress. Zhang X, Eladawi MA, Ryan WG, Fan X, Prevoznik S, Devale T, Ramnani B, Malathi K, Sibille E, Mccullumsmith R, Tomoda T, Shukla R.PNAS Nexus. 2023 Oct 10;2(10):pgad299. doi: 10.1093/pnasnexus/pgad299. eCollection 2023 Oct.PMID: 37822767
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Viral Hemorrhagic Septicemia Virus Activates Integrated Stress Response Pathway and Induces Stress Granules to Regulate Virus Replication. Ramnani B, Powell S, Shetty AG, Manivannan P, Hibbard BR, Leaman DW, Malathi K*. Viruses. 2023 Feb 7;15(2):466. doi: 10.3390/v15020466.PMID: 36851680 (*Communicating author)
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ABCE1 Regulates RNase L-Induced Autophagy during Viral Infections. Ramnani B, Manivannan P, Jaggernauth S, Malathi K*. Viruses. 2021 Feb 18;13(2):315. doi: 10.3390/v13020315.PMID: 33670646 (*Communicating author).
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RNase L amplifies interferon signaling by inducing PKR-mediated antiviral stress granules. Manivannan P, Siddiqui MA, Malathi K*. J Virol. 2020 Jun 16;94(13):e00205-20. doi: 10.1128/JVI.00205-20. (*Communicating author). (Spotlight in Journal of Virology)
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Effect of the Viral Hemorrhagic Septicemia Virus Nonvirion Protein on Translation via PERK-eIF2α Pathway. Shelby Powell Kesterson , Jeffery Ringiesn, Vikram N. Vakharia, Brian S. Shepherd, Douglas W. Leaman,* and Krishnamurthy Malathi* Viruses. 2020 Apr 30;12(5):499. doi: 10.3390/v12050499. PMID: 32365817 (*Communicating author).
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RNase L Induces Expression of A Novel Serine/Threonine Protein Kinase, DRAK1, to Promote Apoptosis. Manivannan P**, Reddy V**, Mukherjee S, Clark KN#, Malathi K*. Int J Mol Sci. 2019 Jul 19;20(14). pii: E3535. doi: 10.3390/ijms20143535. PMID: 31330998.(**Equal contribution) (*Communicating author).
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Role of Viral Hemorrhagic Septicemia Virus (VHSV) Matrix (M) Protein in Suppressing Host Transcription. Qi Ke, Wade Weaver, Adam Pore, Bartolomeo Gorgoglione, Julia Wilschutte, Peng Xiao, Brian Shepherd, Allyn Spear, Krishnamurthy Malathi, Carol A. Stepien, Vikram Vakharia, and Douglas Leaman. J Virol. 2017 Jul 26. pii: JVI.00279-17. doi: 10.1128/JVI.00279-17.PMID:28747493
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Atypical Centrioles are Present in Tribolium Sperm. E.L. Fishman, Kyoung Jo, Andrew Ha, Rachel Royfman, Ashtyn Zinn, Malathi Krishnamurthy, Courtney Clark-Hatchel, Yoshi Tomoyasu and Tomer Avidor-Reiss. Open Biol. 2017 Mar;7(3). pii: 160334. doi: 10.1098/rsob.160334. PMID:28298310
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RNase L suppresses androgen receptor signaling, cell migration and matrix metalloproteinase activity in prostate cancer cells. Shubham Dayal**, Jun Zhou, Praveen Manivannan**, Mohammad Adnan Siddiqui**, Omaima Farid Ahmad#, Matthew Clark, Sahezeel Awadia, Rafael Garcia-Mata, Lirim Shemshedini and Krishnamurthy Malathi*. Int J Mol Sci. 2017 Mar 1;18(3). pii: E529. doi: 10.3390/ijms18030529. PMID: 2825703. (*Communicating author).
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The Roles of RNase-L in Antimicrobial Immunity and the Cytoskeleton-Associated Innate Response. Ezelle HJ, Malathi K, Hassel BA. Int J Mol Sci. 2016 Jan 8;17(1). pii: E74. doi: 10.3390/ijms17010074. PMID: 26760998.
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“Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy” Klionsky, D et al., Autophagy. 2016 Jan 2;12(1):1-222. PMID: 26799652
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RNase L cleavage products promote switch from autophagy to apoptosis by caspase-mediated cleavage of Beclin-1. Siddiqui, MA**, Mukherjee, S, Manivannan, P** and Malathi K* Int. J. Mol. Sci. 2015, 16, 17611-17636; doi:10.3390/ijms160817611. PMID: 26263979 (*Communicating author).
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RNase L interacts with Filamin A to regulate actin dynamics and barrier function for viral entry. Malathi K*, Siddiqui MA**, Dayal S**, Naji M#, Ezelle HJ, Zeng C, Zhou A, Hassel BA. MBio. 2014 Oct 28;5(6):e02012. doi: 10.1128/mBio.02012-14.PMID:25352621(*Communicating author).
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RNase L contributes to experimentally induced type 1 diabetes onset in mice. Zeng C, Yi X, Zipris D, Liu H, Zhang L, Zheng Q, Malathi K, Jin G, Zhou A. J Endocrinol. 2014 Dec;223(3):277-87. doi: 10.1530/JOE-14-0509. Epub 2014 Oct 6. PMID:25287058.
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Epigallocatechin-3-gallate suppresses proinflammatory cytokines and chemokines induced by Toll-like receptor 9 agonists in prostate cancer cells. Mukherjee S, Siddiqui MA**, Dayal S**, Ayoub YZ# and Malathi K*. J Inflamm Res. Jun 17;7:89-101, 2014 (*Communicating author).
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Siddiqui MA**, Malathi K*. RNase L induces autophagy via c-Jun N-terminal kinase and double-stranded RNA-dependent protein kinase signaling pathways. J Biol Chem. 2012 Dec 21;287(52):43651-64. doi: 10.1074/jbc.M112.399964. PMID: 23109342 (*Communicating author).
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Malathi K, Saito T, Crochet N, Barton DJ, Gale M Jr, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 2010 Nov;16(11):2108-19. doi: 10.1261/rna.2244210. PMID: 20833746.
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Malathi K, Dong B, Gale M and Silverman RH. Small self RNA generated by RNase L amplifies Antiviral Innate Immunity. Nature. 2007 Aug 16;448(7155):816-9. doi: 10.1038/nature06042. PMID: 17653195.
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Dong B, Kim S, Hong S, Das Gupta J, Malathi K, Klein EA, Ganem D, Derisi JL, Chow SA, Silverman RH. From the Cover: An infectious retrovirus susceptible to an IFN antiviral pathway from human prostate tumors. Proc. Natl. Acad. Sci. U.S.A, Jan 30;104(5):1655-60, 2007.
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Molinaro RJ, Jha BK, Malathi K, Varambally S, Chinnaiyan AM, Silverman RH. Selection and cloning of poly(rC)-binding protein 2 and Raf kinase inhibitor protein RNA activators of 2',5'-oligoadenylate synthetase from prostate cancer cells. Nucleic Acids Res. 34(22):6684-95, 2006.
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Malathi, K., Paranjape, J.M., Bulanova, E., Shim, M., Guenther-Johnson, J.M., Faber, P.W., Eling, T.E., Williams, B.R.G., and Silverman, R.H. A novel transcriptional signaling pathway in the interferon system mediated by 2'-5'-oligoadenylate activation of RNase L. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14533-8. doi: 10.1073/pnas.0507551102. PMID: 16203993.
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Zhou, A., Molinaro, R.J., Malathi, K., and Silverman, R.H. Mapping of the human RNASEL promoter and expression in cancer and normal cells. J. Interferon & Cyt. Res., 25, 595-603, 2005.
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Malathi K, Li X, Krizanova O, Ondrias K, Sperber K, Ablamunits V, Jayaraman T. Cdc2/cyclin B1 interacts with and modulates inositol 1,4,5-trisphosphate receptor (type 1) functions. J Immunol. 2005 Nov 1;175(9):6205-10.
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Malathi K, Paranjape JM, Ganapathi R, Silverman RH. HPC1/RNASEL mediates apoptosis of prostate cancer cells treated with 2',5'-oligoadenylates, topoisomerase I inhibitors, and tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res. 2004 Dec 15;64(24):9144-51.
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Tantral, L., Malathi, K., Kohyama, S., Silane, M., Berenstein, A. and Jayaraman, T. Intracellular calcium release is required for caspase-3 and –9 activation. Cell Biochem. and Function. 22(1): 35-40. 2004.
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Malathi, K., Higaki, K., Tinkelenberg, A.H., Balderes, D.A., Almanzar, D., Wilcox, L., Erdeniz, N., Redican, F., Padamsee, M, Liu, Y., Khan, S., Alcantara, F., Carstea, E.D., Morris, J.A., and Sturley, S.L. Mutagenesis of the putative sterol sensing domain of the yeast Niemann Pick C related protein reveals a primordial role in subcellular sphingolipid distribution. J Cell Biol.164(4):547-56. 2004
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Editorial on the above paper ` A primordial mover of sphingolipids’ in J. Cell Biol. 164(4): 476, 2004.
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Malathi, K., Kohyama, S., Ho, M., Soghoian, D., Li, X., Silane, M., Berenstein, A., and Jayaraman, T. Inositol 1,4,5-triphosphate receptor (type 1) phosphorylation and modulation by cdc2. J. Cell. Biochem.90(6): 1186-96, 2003.
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Malathi, K., Xiao, Y., and Mitchell, A.P. Catalytic roles of yeast GSK3beta/shaggy homolog Rim11p in meiotic gene activation. Genetics. 153:1145-1152. 1999.
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Malathi, K., Xiao, Y., and Mitchell.A.P. Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolg Rim11p. Mol. Cell. Biol. 17(12): 7230-7236. 1997.
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Malathi, K., Ganesan, K., and Datta, A. Identification of a putative transcription factor in C.albicans that can complement the mating defect of S.cerevisiae ste12 mutants. J. Biol. Chem. 269: 22945-51. 1994.
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Singh,P., Ganesan, K. , Malathi, K, Ghosh, D., and Datta, A. ACPR, a STE12 homologue from C.albicans, is a strong inducer of pseudohyphae in S.cerevisiae haploids and diploids. Biochem. Biophys. Res. Comm. 205 (2) 1079-85. 1994.