top of page
RNase L-Filamin A interaction in prostate cancer
We have demonstrated interaction of RNase L with actin-binding protein, Filamin A. Filamin A also interacts with Androgen Receptor (AR) and inhibits transcriptional activity of AR. Published studies have shown that RNase L interacts with AR, and the interaction is stimulated by androgens. Also, mutations in RNASEL correlate with incidence of hereditary prostate cancer. In light of these correlations, we are investigating the role of RNase L in prostate cancer.
bottom of page